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Research Outline      2016-01-06 14:30:05

Coronary artery pattern and its implications in management of transposition of the great arteries. My colleagues and I are interested in the evolution of coronary artery pattern and its implications in surgical management of transposition of the great arteries (TGA). Embryologically, the coronary artery develops after septation of the aortopulmonary trunk and pierces the aortic sinus at the nearest site after aortopulmonary rotation. We found that the pattern of the coronary artery is statistically dependent on aortopulmonary rotation, and thus proposed a new categorization scheme based on the aortic root rotation. We also found that, in addition to the short-axis rotation, which is related to the juxtacommissural origin of the coronary artery, there is also a long-axis rotation, which is related to high takeoff of the coronary artery. On the basis of these findings, we have proposed appropriate diagnostic and surgical techniques to manage different coronary artery patterns in patients with TGA. Our categorization of coronary artery pattern can be applied to all congenital cardiac defects and normal hearts. Recently, we developed the party-wall concept and an in situ transfer technique to transfer the coronary, pulmonary arteries and aorta. We are also investigating the etiology of and ways to avoid suprapulmonary stenosis,  reconstructed the transposed great arteries, and septated the univentrricular heart in spiral fashion.