Researcher's Profile

JUI-CHANG TSAI (蔡瑞章)

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Research Outline      2014-03-26 16:59:06

In Center for Optoelectronic Medicine, my colleagues and I are interested in the mechanism of photodynamic therapy (PDT) and the clinical applications of PDT for the treatment of cancers, especially malignant gliomas. Recently, we are also interested in photodynamic diagnosis (PDD) and fluorescence guided resection (FGR) of malignant gliomas. We also studied on photodynamic inactivation (PDI) for bacteria, especially multidrug resistant bacteria, and investigated the mechanism of PDI. In cooperation with Prof. Yuan Luo (駱遠), we are developing a fast optical holographic spatial-spectral biomedical imaging technique, which is a novel imaging technique and offers capability to acquire multi-depth resolved images and spectral information of tissue samples. We hope this technique can provide real-time tissue diagnosis during operation in the near future. In cooperation with Prof. Sung-Liang Yu (俞松良), we also performed basic research using the brain tumor specimens collected during operation. We first profiled 1,145 microRNAs of 30 glioma FFPE specimens by microRNA Bead Array. We found that microRNA-328 is correlated with prolonged survival of glioblastoma multiforme patients. These findings might develop a prognostic marker and new therapeutic strategies for the treatment of this devastating disease in the future.