YEN-CHING CHEN (程蘊菁)ORCID Follow
|Profile 2016-07-12 14:49:59|
|Career and Experience||
Honor & Awards
Honor & Awards for Postdoctoral Fellow and Students
Research Outline 2015-02-10 11:13:01
Our lab focuses on research in the elderly. Currently, we have projects on cognitive function, dementia and osteoporosis in Taiwanese elders (supported by Ministry of science and Technology and international) and international collaborative projects on prostate cancer. Our lab includes clinicians, graduate and undergraduate students. We also have extensive collaboration with clinicians of different specialties (geriatrics, neurology, gastroenterology, ophthalmology and cardiology) and experts from multidisplines (biostatistics, nutrition, metablome, and spatiotemporal environment). The goals of our lab is to:
dentify clinical, genomic and environmental factors for predicting specific outcomes (dementia, cognitive impairment, osteoporosis, and prostate cancer) at an early stage.
Preventing these health outcomes via early intervention.
Arouse the attention on research in the elderly.
For those who are interested in our research, welcome to join us!
Our recent research includes epidemiologic studies on dementia, cognitive function, osteoporosis and prostate cancer, which are summarized below.
Cognitive Function and Dementia
By the end of 2013, the proportion of elderly population was greater than 12% in Taiwan and our aging rate ranks the 2nd in the world. Because of the elevation of living standard and the elongation of lifespan, dementia become an important health issue in the elderly. In the USA, dementia is the 6th leading cause of death among the elderly in 2013. In Taiwan, the number of demented persons has been greater than 170,000 in the elderly. Base on a recent large-scale survey in Taiwan (2011-2012), 8% of elders (people aged 65 or older) have all dementia (very mild dementia plus dementia with Clinical Dementia Rating ≧ 1); this number increased to 22% for elders aged 85 to 89. The early diagnosis of dementia is not easy and the effective treatment of this complex disease is currently unavailable. Alzheimer's disease is the most common neurodegeneration disease and subtype of dementia. Because the average survival time for patients with is about 8 to 10 years, taking care of demented people introduce a heavy burden to their families as well as the society and the medical system.
Chronic inflammation is an innate immune response. Research has related chronic inflammation to the risk of dementia. However, genetic epidemiologic studies in dementia are incomplete and data are sparse in Asian populations. Because genetic markers in blood are useful tools to predict the risk of dementia, we have collaborated with 3 teaching hospitals to assess the association of polymorphisms of inflammatory genes and the risk of dementia. In addition to candidate-gene studies, we also have a genome-wide association study (GWAS) on Alzheimer’s disease in Taiwanese elders.
Dementia is a complex disease, its occurrence related to clinical factors, genetic susceptibility, lifestyle (e.g. physical activities and diet) and environmental factors (e.g., air pollution). Therefore, we hope to integrate various factors for predicting the risk of dementia at an earlier stage, i.e., mild cognitive impairment or the preclinical stage.
About 10 million and 34 million of Americans have osteoporosis and low bone mass, respectively. Among them, 80% are women who are at high risk of fracture. Osteoporosis is a common health issue among postmenopausal women and over 50% of this population has increased risk of fracture. World Health Organization reported that osteoporosis has been an important health issue secondary to coronary heart disease. Although osteoporosis is preventable and curable, no clear symptoms could be identified before the occurrence of fracture, which is associated with higher mortality. Family studies found that 30% to 80% of variations of bone mineral density were attributable to genetic factors. However, previous candidate-gene association studies observed inconsistent findings. Therefore, the etiology of osteoporosis remains unclear. Recently, GWASs found that some single nucleotide polymorphisms (SNPs) were associated with bone mineral density and osteoporosis. In addition to genetic markers, our lab also look into metabolome, various clinical factors and lifestyle in relation to the risk of low bone mineral density.
Prostate Cancer Project
Prostate cancer (PCa) is the most common non-skin cancer and the 2nd cancer cause of death among men in the USA. PCa is the 6th common cancer and its incidence remains elevated in Taiwan (Cancer Registry System, 2011). Since 2003, we have collaborated with Harvard School of Public Health and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School on the prostate cancer project. Several articles have been published based on the data from Health Professionals Follow-Up Study (HPFS) with a recent work on the interactions between TLR4 genetic polymorphisms and the infection of Trichomonas vaginalis. We also have papers for the Prostate Cohort Consortium Project, National Cancer Institute, USA. Recently, we had a PCa international collaborative project that was led by us, this meta-analysis assessed genetic polymorphisms of TLR4 and PCa has been published in 2014, which may help unraveling the etiology of PCa.
Publications 52 2015-06-01 16:07:18
Ordered by publish date
- Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia. 2015 -02 | journal-article Scopus: 2 Web of Science: 2 Impact Factor: 1.969
- Religious affiliation and the risk of dementia in Taiwanese elderly Archives of Gerontology and Geriatrics 2015 | journal-article vol.60,no.3,page.501-506 Scopus: 2 Web of Science: 1 Impact Factor: 2.086
- Sequence variants of peroxisome proliferator-activated receptor-gamma gene and the clinical courses of patients with end-stage renal disease Disease Markers 2015 | journal-article vol.2015 Scopus: 3 Web of Science: 0 Impact Factor: 2.348
- Association between Secreted Phosphoprotein-1 (SPP1) polymorphisms and low bone mineral density in women PLoS ONE 2014 | journal-article vol.9,no.5 Scopus: 0 Web of Science: 0 Impact Factor: 2.806
- Association between the metabolome and low bone mineral density in taiwanese women determined by 1H NMR spectroscopy Journal of Bone and Mineral Research 2014 | journal-article vol.29,no.1,page.212-222 Scopus: 9 Web of Science: 8 Impact Factor: 6.284
- Dementia: A focused review Journal of Internal Medicine of Taiwan 2014 | journal-article vol.25,no.3,page.151-157
- Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study PLoS ONE 2014 | journal-article vol.9,no.5 Scopus: 5 Web of Science: 5 Impact Factor: 2.806
- Leisure activities, apolipoprotein E e4 status, and the risk of dementia. 2014 -11 | journal-article
- Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: A systematic review and meta-analysis PLoS ONE 2014 | journal-article vol.9,no.10 Scopus: 3 Web of Science: 3 Impact Factor: 2.806
- 失智症之重點回顧 2014 | journal-article
- CHRNA7 polymorphisms and response to cholinesterase inhibitors in Alzheimer's disease PLoS ONE 2013 | journal-article vol.8,no.12 Scopus: 7 Web of Science: 6 Impact Factor: 2.806
- Leisure activities, apolipoprotein E e4 status, and the risk of dementia Journal of the Formosan Medical Association 2013 | journal-article Scopus: 2 Web of Science: 2 Impact Factor: 1.969
- Prospective study of effect modification by Toll-like receptor 4 variation on the association between Trichomonas vaginalis serostatus and prostate cancer Cancer Causes and Control 2013 | journal-article vol.24,no.1,page.175-180 Scopus: 1 Web of Science: 0 Impact Factor: 2.51
- Sequence variants of the aging gene CISD2 and the risk for Alzheimer's disease Journal of the Formosan Medical Association 2013 | journal-article Scopus: 0 Web of Science: 0 Impact Factor: 1.969
- Genetic polymorphisms of clusterin gene are associated with a decreased risk of Alzheimer's disease European Journal of Epidemiology 2012 | journal-article vol.27,no.1,page.73-75 Scopus: 10 Web of Science: 9 Impact Factor: 7.226
- Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease Journal of Negative Results in BioMedicine 2012 | journal-article vol.11,no.1 Scopus: 6
- Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease Journal of Neuroinflammation 2012 | journal-article vol.9 Scopus: 19 Web of Science: 18 Impact Factor: 5.102
- Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease PLoS ONE 2012 | journal-article vol.7,no.12 Scopus: 15 Web of Science: 15 Impact Factor: 2.806
- The authors' reply European Journal of Epidemiology 2012 | journal-article vol.27,no.9 Scopus: 2
- Use of germline polymorphisms in predicting concurrent chemoradiotherapy response in esophageal cancer International Journal of Radiation Oncology Biology Physics 2012 | journal-article vol.82,no.5,page.1996-2003 Scopus: 8 Web of Science: 7 Impact Factor: 5.133
- Genetic polymorphisms of a novel vascular susceptibility gene, ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease PLoS ONE 2011 | journal-article vol.6,no.6 Scopus: 9 Web of Science: 8 Impact Factor: 2.806
- Genetic susceptibility to second-hand smoke Handbook of Smoking and Health 2011 | book page.157-206
- Genetic variability in serotonin receptor and transporter genes may influence risk for tardive dyskinesia in chronic schizophrenia Psychiatry Research 2011 | journal-article vol.188,no.1,page.175-176 Scopus: 6 Web of Science: 5 Impact Factor: 2.528
- Body mass index (BMI) at an early age and the risk of dementia. Archives of gerontology and geriatrics 2010 | journal-article vol.50 Suppl 1
- Cancer and inflammation: Promise for biologic therapy Journal of Immunotherapy 2010 | journal-article vol.33,no.4,page.335-351 Scopus: 160 Web of Science: 143 Impact Factor: 3.915
- Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins Pharmacogenomics 2010 | journal-article vol.11,no.3,page.309-317 Scopus: 19 Web of Science: 16 Impact Factor: 2.35
- Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population Cancer Causes and Control 2010 | journal-article vol.21,no.5,page.771-776 Scopus: 8 Web of Science: 7 Impact Factor: 2.51
- Association between sequence variant of c.553 G > T in the apolipoprotein A5 gene and metabolic syndrome, insulin resistance, and carotid atherosclerosis Translational Research 2009 | journal-article vol.154,no.3,page.133-141 Scopus: 7
- Human Papilloma Virus and Female Lung Adenocarcinoma Seminars in Oncology 2009 | journal-article vol.36,no.6,page.542-552 Scopus: 24 Web of Science: 17 Impact Factor: 6.212
- Long-term outcome of allogeneic human leukocyte antigen-matched sibling-donor peripheral blood stem cell transplantation in leukaemia patients Hong Kong Medical Journal 2009 | journal-article vol.15,no.3 SUPP3,page.31-34
- Pediatric empyema: Outcome analysis of thoracoscopic management Journal of Thoracic and Cardiovascular Surgery 2009 | journal-article vol.137,no.5,page.1195-1199 Scopus: 15 Web of Science: 14 Impact Factor: 4.446
- Risk factors for dementia Journal of the Formosan Medical Association 2009 | journal-article vol.108,no.10,page.754-764 Scopus: 70
- Association between genetic polymorphisms of Macrophage scavenger receptor 1 gene and risk of prostate cancer in the health professionals follow-up study Cancer Epidemiology Biomarkers and Prevention 2008 | journal-article vol.17,no.4,page.1001-1003 Scopus: 5 Web of Science: 3 Impact Factor: 4.142
- Family history of prostate and breast cancer and the risk of prostate cancer in the PSA era Prostate 2008 | journal-article vol.68,no.14,page.1582-1591 Scopus: 27 Web of Science: 26 Impact Factor: 3.82
- Sequence variants of elaC homolog 2 (Escherichia coli) (ELAC2) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study Carcinogenesis 2008 | journal-article vol.29,no.5,page.999-1004 Scopus: 8 Web of Science: 6 Impact Factor: 5.105
- Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions Environmental Health Perspectives 2007 | journal-article vol.115,no.3,page.341-345 Scopus: 71 Web of Science: 59 Impact Factor: 9.776
- Association between toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer Cancer Epidemiology Biomarkers and Prevention 2007 | journal-article vol.16,no.10,page.1982-1989 Scopus: 31 Web of Science: 26 Impact Factor: 4.142
- Sequence variants of estrogen receptor B and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium Cancer Epidemiology Biomarkers and Prevention 2007 | journal-article vol.16,no.10,page.1973-1981 Scopus: 23 Web of Science: 21 Impact Factor: 4.142
- Occurrence and treatment of suspected pneumonia in long-term care residents dying with advanced dementia Journal of the American Geriatrics Society 2006 | journal-article vol.54,no.2,page.290-295 Scopus: 52 Web of Science: 45 Impact Factor: 4.388
- Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer PLoS Genetics 2005 | journal-article vol.1,no.5,page.603-613 Scopus: 6 Web of Science: 43 Impact Factor: 6.1
- Interaction between environmental tobacco smoke and arsenic methylation ability on the risk of bladder cancer Cancer Causes and Control 2005 | journal-article vol.16,no.2,page.75-81 Scopus: 47 Web of Science: 38 Impact Factor: 2.51
- Molecular epidemiology of cancer Ca-A Cancer Journal for Clinicians 2005 | journal-article vol.55,no.1,page.45-54
- Molecular epidemiology of cancer. 2005 | journal-article
- Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer Cancer Research 2005 | journal-article vol.65,no.24,page.11771-11778 Scopus: 132 Web of Science: 118 Impact Factor: 9.122
- Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era Cancer Epidemiology Biomarkers and Prevention 2005 | journal-article vol.14,no.5,page.1262-1269 Scopus: 157 Web of Science: 146 Impact Factor: 4.142
- Lung adenocarcinoma and human papillomavirus infection Cancer 2004 | journal-article vol.101,no.6,page.1428-1436 Scopus: 58 Web of Science: 45 Impact Factor: 5.997
- Polymorphisms in GSTT1 and p53 and urinary transitional cell carcinoma in south-western Taiwan: A preliminary study Biomarkers 2004 | journal-article vol.9,no.4-5,page.386-394 Scopus: 29 Web of Science: 25 Impact Factor: 2.006
- Arsenic methylation and bladder cancer risk in Taiwan Cancer Causes and Control 2003 | journal-article vol.14,no.4,page.303-310 Scopus: 176 Web of Science: 160 Impact Factor: 2.51
- Arsenic methylation and skin cancer risk in Southwestern Taiwan Journal of Occupational and Environmental Medicine 2003 | journal-article vol.45,no.3,page.241-248 Scopus: 161 Web of Science: 149 Impact Factor: 1.861
- Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering 2003 | journal-article vol.38,no.1,page.201-211 Scopus: 30 Web of Science: 28 Impact Factor: 1.425
- Stability of arsenic species and insoluble arsenic in human urine Cancer Epidemiology Biomarkers and Prevention 2002 | journal-article vol.11,no.11,page.1427-1433
- Stability of arsenic species and insoluble arsenic in human urine. 2002 -11 | journal-article
Projects 8 2015-01-30 16:29:19
Ordered by project period
Utility of Combinations of Biomarkers, Dietary Patterns, and Clinical Risk Factors to Predict Cognitive Change in the Elderly (運用整合性生物指標、飲食型態及臨床風險因子預測老年人認知功能變化)Project Number : NSC101-2314-B002-126-MY3 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳人豪 Funding IC : 科技部 Project Period : 10308~10407
Utility of Combinations of Biomarkers, Dietary Patterns, and Clinical Risk Factors to Predict Cognitive Change in the Elderly (運用整合性生物指標、飲食型態及臨床風險因子預測老年人認知功能變化)Project Number : NSC101-2314-B002-126-MY3 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳人豪 Funding IC : 行政院國家科學委員會 Project Period : 10208~10307
Utility of Combinations of Biomarkers, Dietary Patterns, and Clinical Risk Factors to Predict Cognitive Change in the Elderly (運用整合性生物指標、飲食型態及臨床風險因子預測老年人認知功能變化)Project Number : NSC101-2314-B002-126-MY3 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳人豪 Funding IC : 行政院國家科學委員會 Project Period : 10108~10207
Metabolomic-Genetic Profile, Dietary Patterns, and Cognitive Function in the Elderly (代謝質體-基因檔案、飲食型態與認知功能之老年人研究)Project Number : NSC100-2314-B002-103 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳人豪 Funding IC : 行政院國家科學委員會 Project Period : 10008~10107
Copy Number Variations, Expression of Inflammatory Cytokines and the Risk of Dementia---A Two-Stage Genome-Wide Association Study (拷貝數變異、細胞激素表現與失智症的風險---兩階段全基因組關聯研究)Project Number : NSC97-2314-B002-168-MY3 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳人豪, 葉炳強 Funding IC : 行政院國家科學委員會 Project Period : 9908~10007
Copy Number Variations, Expression of Inflammatory Cytokines and the Risk of Dementia---A Two-Stage Genome-Wide Association Study (拷貝數變異、細胞激素表現與失智症的風險---兩階段全基因組關聯研究)Project Number : NSC97-2314-B002-168-MY3 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 葉炳強, 陳人豪 Funding IC : 行政院國家科學委員會 Project Period : 9808~9907
Copy Number Variations, Expression of Inflammatory Cytokines and the Risk of Dementia---A Two-Stage Genome-Wide Association Study (拷貝數變異、細胞激素表現與失智症的風險---兩階段全基因組關聯研究)Project Number : NSC97-2314-B002-168-MY3 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳人豪, 葉炳強 Funding IC : 行政院國家科學委員會 Project Period : 9708~9807
Genetic Epidemiologic Study of Sequence Variants of Inflammatory Genes and Susceptibility to Dementia in Taiwan (臺灣地區發炎基因多型性與失智症之遺傳流行病學研究)Project Number : NSC96-2314-B002-197 PI : YEN-CHING CHEN (程蘊菁) Co-PI : 陳達夫, 邱銘章, 葉炳強 Funding IC : 行政院國家科學委員會 Project Period : 9610~9707